Another study showed that, in cultured human podocytes, angiotensin II up-regulated the expression of the Snail via Notch1 activation and promoted Snail protein translocation to the nucleus, accentuating the function of angiotensin II in DKD development and annotating the considerable role of pharmacological inhibition of the renin-angiotensin system in patients with DN [22]. This evidence concerns the gene NOTCH1 and liver dysplastic nodule.