IHC examination revealed that the LN patients’ renal biopsies displayed an intense and diffuse Roquin-1 and Roquin-2 staining in glomeruli, generating a higher expression score in LN patients compared to controls (2.33 ± 0.2 vs. 1 ± 0.5 and 2.6 ± 0.48 vs. 1.12 ± 0.22; p = 0.044 and p = 0.038, respectively) (Figure 5A,C). This evidence concerns the gene RC3H1 and lobular neoplasia.