These two proteins contribute to the maintenance of immune tolerance and the prevention of inflammation and autoimmune diseases by post-transcriptional regulation of the expression of different cytokines mRNAs such as TNF-α and IL6, mRNAs of costimulatory molecules including Inducible T Cell Costimulator (ICOS) and OX40, as well as mRNAs of transcription factors [16]. The gene discussed is ICOS; the disease is autoimmune disease.