In basal conditions, the mRNA gene expression of TNF-α, Il-6, and ICOS revealed no statistically significant difference between PBMCs of LN patients and HC (0.155 ± 0.064 vs. 0.169 ± 0.041, 0.093 ± 0.07 vs. 0.048 ± 0.016, 0.02 ± 0.008 vs. 0.028 ± 0.004, respectively). This evidence concerns the gene ICOS and lobular neoplasia.