SIK2 and breast cancer: Through a heat map analysis of the 20 selected DE mRNAs, 14 mRNAs (HADH, CPN2, ADAM33, TDRD10, SNF1LK2, HBA2, KCNIP2, EPB42, PYGM, CEP68, ING3, EMCN, SYF2, DTWD1) were found to be downregulated in breast cancer tissues and six mRNAs (ZNF8, TOMM40, EVPL, EPN3, AP1M2, SPINT2) were upregulated in breast cancer tissues (Figure 2).