TDP-43 abnormalities have also been observed in other neurodegenerative diseases as well, mainly in ALS, the other end of the ALS-FTD spectrum, but also in AD, limbic-predominant age-related TDP-43 encephalopathy (LATE), cerebral age-related TDP-43 with sclerosis (CARTS), and some other even rarer conditions [27,46,47]. This evidence concerns the gene TARDBP and frontotemporal dementia.