CD4 and central nervous system cancer: In low-grade glioma, MEG3 was negatively correlated with infiltrating B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells, but in the case of glioblastoma multiforme, MEG3 was positively correlated with infiltrating CD8+ T cells and negatively correlated with infiltrating dendritic cells [54].