Cytokines are considered to play a critical orchestrating role in the chronic inflammation observed in various inflammatory disorders, such as COPD, and many of them signal through the Janus kinase (JAK) signal transducer and the activator of signal transducer and activator of transcription (STAT) pathways and are produced as a consequence of JAK-STAT pathway signaling [26]. This evidence concerns the gene SOAT1 and chronic obstructive pulmonary disease.