Adhesion molecules, such as integrins, L1 cell adhesion molecule (L1CAM), cell division cycle 42 (CDC42), and ephrin-B2 (EB2), are required for the morphological changes occurring in glioma co-opting cells, leading to the emergence of a mesenchymal-like phenotype [31,32,33,34]. The gene discussed is L1CAM; the disease is central nervous system cancer.