This observation is particularly interesting if we consider that, in an animal study, it has been demonstrated that PTHrP acts as a growth factor for pancreatic beta-cells [92] and that, in chronic pancreatitis, PTHrP functions as a mediator of proinflammatory and profibrotic cytokines, which in turn regulate PTHrP expression [93]. Here, PTHLH is linked to chronic pancreatitis.