EGFR and head and neck squamous cell carcinoma: Bioinformatics and statistical approaches have revealed that FAT1 mutation is prevalent in HPV-negative HNSCC and is associated with human epidermal growth factor receptor 3 (HER3) activation and reduced epidermal growth factor receptor (EGFR) expression, suggesting that FAT1 mutation may confer resistance to EGFR-targeted therapy [70].