YAP/TAZ plays a tumor suppressive role by inducing integrin alpha 5 and beta 5 in neural/neuroendocrine and RB transcriptional corepressor 1 (RB1)−/− solid cancers, such as retinoblastoma, small cell lung cancer, and neuroendocrine prostate cancer [36]. This evidence concerns the gene RB1 and retinoblastoma.