TIMP-1 forms a complex with CD63 and integrin β1 on collagen, and then activates Src and RhoA, resulting in F-actin assembly that inactivates LATS1/2 and activates YAP/TAZ in many types of cancer cell lines, including HNSCC [95,96]. This evidence concerns the gene WWTR1 and head and neck squamous cell carcinoma.