Moreover, during infection, there is an increase in proinflammatory cytokines (interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-18, tumor necrosis factor (TNF)-α, IFN-γ, leading to a disbalance in immune surveillance mechanisms and changes in the tissue environment [38,39,40]. The gene discussed is IFNG; the disease is infection.