With the use of miRNA transcriptomics, it has been recently shown that the cytoskeleton and myocilin, encoded by MYOC, were involved in cryptococcal brain dissemination by modulating the Trojan horse pathway in mice and macaques, and provide a possible explanation for higher incidences of cryptococcal meningoencephalitis in HIV/AIDS patients, who often have dysfunctional immune cell cytoskeletons [50]. The gene discussed is MYOC; the disease is AIDS.