The ELISA test with a proprietary MVista®Histoplasma antigen used for evaluating the acute pulmonary form of histoplasmosis detected IgG antibodies in 87%, IgM antibodies in 67%, and IgG and/or IgM antibodies in 89% of patients with this clinical form of histoplasmosis [68]. This evidence concerns the gene CD40LG and histoplasmosis.