ABCG1 and leukemia: Since ABCG1 is implicated in the active transport of cholesterol and other lipoproteins [34,35], together with the observed synergistic effect of imatinib and antilipidemic drugs in anti-leukemia activity [36,37], we hypothesize that genetic variations in ABCG1 play a role in imatinib excretion mediated by possible changes in the lipidic composition of the cellular membrane.