We found no association between severe dental disease and the severity of the underlying SCD; homozygous and double heterozygous patients had similar incidence whilst severe dental disease did not differ according to the history of severe sickle-related complication including frequent painful VOCs and did not appear to be affected by baseline Hb or rate of haemolysis. The gene discussed is GSTM1; the disease is Schnyder corneal dystrophy.