CYP21A2 and hyperandrogenism: This form is caused by CYP21A2 variants that impair the synthesis of 11-deoxycortisol and deoxycorticosterone (DOC), with a resulting lack of cortisol and aldosterone secretion and the accumulation of 17-OH-progesterone (17-OH-P) and progesterone, respectively (Figure 1), producing hyperandrogenism.