MTOR and polycystic ovary syndrome: In contrast, the overactivation of mTOR-related pathways in in vitro or animal studies has been associated with ovarian aging and the pathogenesis of premature ovarian insufficiency due to massive maturation of primordial follicles [35,36], polycystic ovary syndrome (PCOS) [37,38], endometriosis [39], and ovarian cancers [40,41,42].