Reviewing the most significant studies, it was found that in the CLARINET FORTE phase II trial of lanreotide 120 mg every 14 days in patients with midgut (N = 79) or pancreatic NET (N = 79), a dramatic decrease in median PFS was observed in tumors with Ki67 >10% as compared to those with a lower proliferation index, in both the midgut (5.5 vs. 8.6 months, respectively) and the pancreatic cohort (2.8 vs. 8.0 months, respectively) [13]. This evidence concerns the gene MKI67 and pancreatic neuroendocrine tumor.