In a Japanese population, after adjusting for age, sex, diastolic blood pressure, DM, total cholesterol, body mass index, albumin, electrocardiogram abnormalities, eGFR, smoking habits, alcohol intake, and regular exercise, the highest (males ≥ 43.8%, females ≥ 43.8%) and lowest (males ≤ 44.7%, females ≤ 39.3%) Hct quartiles were significantly associated with the development of ischemic stroke [26]. This evidence concerns the gene ALB and ischemic stroke.