TBX22 and ankyloglossia: Mutations in TBX22 are associated with X-linked cleft palate and ankyloglossia (OMIM # 303400), which is a disorder characterized by phenotypic heterogeneity ranging from ankyloglossia only to submucous cleft palate, bifid uvula or cleft of the soft and hard palate, all with or without tongue-tie [39].