The cytokine disorders appearing in BD include an increase in the level of pro-inflammatory cytokines and activation of the Th1 response, but in the case of a manic episode, attention is drawn also to the induction of Th2 responses and an increase in anti-inflammatory cytokines such as IL-4, IL-5 and IL-10 [63,65,67,81]. The gene discussed is IL4; the disease is Behcet disease.