Ortiz-Domínguez et al. (2007) describe a significant increase in IL-4 levels and a decrease in IL-6 and IL-1β in patients with BD in the manic phase and a reverse trend in the depressive phase, as well as a significantly higher level of TNF-α and decreased level of IL-2 in both phases [67]. The gene discussed is IL6; the disease is Behcet disease.