Gliomas with intact isocitrate dehydrogenase (IDH) defined as IDH-wild type (IDH-wt), the most common astrocytic gliomas, have as characteristics: very high proliferative activity and cellular synthesis, worse prognosis than their mutated (IDH-mut) counterparts and older age at diagnosis than IDH-mut gliomas. The gene discussed is IDH3A; the disease is central nervous system cancer.