There are reports that heterozygous patients with an inactivating mutation in the ABCC8 gene responsible for the mild form of HH (even those with no history of pancreatectomy) occasionally develop diabetes later in life, and that their family members often have diabetes, which can be successfully treated with sulphonylurea [62,68,69,70,71,72,73]. This evidence concerns the gene ABCC8 and diabetes mellitus.