When we applied the clustering algorithm to the NASH/NAFLD group, we observed differences between two clusters (cluster 1: fourteen subjects; cluster 2: seven patients, respectively); all lower serum levels were reported in patients belonging to cluster 1: BMP-9 (911.6 ± 628.4 vs. 2028.6 ± 481.4 pg/mL, p = 0.01), leptin (4498.8 ± 2702.4 vs. 11963.9 ± 984.2 pg/mL, p <0.001), IL-8 (80.2 ± 63.1 vs. 1168.6 ± 974.8 pg/mL, p < 0.001), and HGF (1069.3 ± 336.2 vs. 2040.7 ± 160.4 pg/mL, p <0.001). This evidence concerns the gene LEP and metabolic dysfunction-associated steatotic liver disease.