In pathological angiogenesis of NAFLD and NASH, there is a strong expression of main pro-angiogenic factors such as vascular endothelial growth factor (VEGF), placenta growth factor (PlGF), Angiopoietin-2 (Ang-2), and platelet derived growth factor (PDGF), which are released by different cell types involved in the progression of chronic liver disease [7]. This evidence concerns the gene ANGPT2 and metabolic dysfunction-associated steatohepatitis.