In vitro, its reduction can increase the immunogenic capability of TAMs, with a significant increase in cytokines, such as IL-2 (lymphocyte T activator) and TNF-α, but also a higher expression of major histocompatibility complex (MHC)-II, with a significant role in antigen presentation and increase in T lymphocyte infiltration numbers and the tumor-reactive responses [36]. Here, TNF is linked to neoplasm.