On the other hand, the combination of a CD47 blockage with cabazitaxel, a microtubule depolymerization inhibitor [122], elicited a strong anti-tumor effect, inducing polarization of TAMs towards an M1 state by the activation of TLR/NF-kB pathways and enhancing the expression of pro-inflammatory cytokines. The gene discussed is NFKB1; the disease is neoplasm.