Primary OutcomeIncident T2DM: The estimated cumulative incidence of T2DM was calculated using unadjusted Cox regression analysis.Secondary OutcomeBody Mass Index (BMI), Waist circumference, and Blood Pressure (systolic and diastolic): Mean of two readings obtained at each visit using standardized methods.Physical activity evaluation using a questionnaireTotal dietary intake: dietary intake as determined by a 24-h recallLipid profile (total cholesterol, triglycerides (TG), and HDL): fasting venous plasma samplingHOMA-IR: ([fasting insulin (mU/L) × fasting glucose (mmol/L)] formula/22·5). This evidence concerns the gene INS and type 2 diabetes mellitus.