TNF and obesity due to melanocortin 4 receptor deficiency: Although training has been shown to be effective in reducing the acute phase protein C-reactive protein (CRP) and cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), there is no consensus on the improvement of CRP, IL-6, and TNF-α in adolescents with obesity through different training modalities [9].