STAT3 is a transcription factor enriched by TRRUST analysis, and the JAK/STAT signaling pathway is related to inflammatory response, oxidative stress, cell injury and apoptosis [48] and can be activated by many pro-inflammatory cytokines such as IL-6 and IL-11 released from the ischemic brain after ischemic stroke [49]. This evidence concerns the gene STAT3 and ischemic stroke.