The results demonstrated that kaempferol may reduce the number of apoptotic cells and regulate the expression of apoptosis-related proteins through the BDNF-TrkB-PI3K/AKT signaling pathway, and alleviated cerebral ischemia-reperfusion injury by inhibiting neutrophil activation, aggregation and infiltration and down-regulating JAK1/STAT3 signaling pathway. Here, AKT1 is linked to brain ischemia.