Moreover, TRAIL bispecific constructs selective for the annexin V, albumin binding domain (ABD), a small cationic linear α-helical peptide selective for tumor cells (CM4), Fn14, tumor molecular targeted peptide 1 (TMTP1), vasostatin have been described, all of which specifically bind to tumor cells and display increased TRAIL-mediated apoptosis [3]. This evidence concerns the gene TNFRSF12A and neoplasm.