The construction of chimeric proteins with the iRGD peptide was used to enhance the tumor permeability of the variable domain from the heavy chain of the anti-epidermal growth factor receptor antibody (anti-EGFR VHH) [12], recombinant analogue of lactaptin (RL2) [13], proapoptotic peptide KLA [14], interleukin-24 (IL-24) [15], and DNA fragmenting factor (DFF40) [16]. Here, EGFR is linked to neoplasm.