Our group made a great effort to elucidate the role of the ECS—and more specifically the CB2—in ischemic cardiomyopathy, and our findings were consistent with the before-mentioned data, showing increased cardiomyocyte apoptosis and infarct size, followed by deteriorated LV function in CB2 deficient mice during repetitive myocardial I/R [7]. Here, CNR2 is linked to ischemic cardiomyopathy.