Authors [51] indicated that deregulation of E-cadherin complexes had a role in cancer progression since most solid tumors were epithelial in origin, indicating that cancer progression might be promoted by E-cadherin loss, mutation, or destabilization due to loss of p120 binding, hence evidence suggested that the E-cadherin/catenin complex was required for epithelial monolayer homeostasis and maintenance [51]. The gene discussed is CDH1; the disease is cancer.