METTL3 and psoriasis: Compared with the Mettl3+/+ group, the Mettl3+/− group showed aggravated psoriasis-like clinical and pathological manifestations (Figure 2B), higher PASI scores (Figure 2C), increased acanthosis (an increase in the thickness of the stratum spinosum of the epidermis), and inflammatory cell infiltration in the skin lesions (Figure 2D), which were most pronounced on day 7.