NFKB1 and Alzheimer disease: For example, the LPS-mediated, ROS- and NF-kB-regulated up-regulation of microRNAs miRNA-30b, miRNA-146a and miRNA-155 in transgenic murine models of AD and in AD are now known to target and down-regulate the expression of important neuron-specific neurofilament and synaptic elements important in supporting and maintaining homeostasis in brain cells and neural signaling capabilities [51,52,57,58,59,60,71] (Figure 2).