Meanwhile, ventricle injection of GSK3β inhibitor caused significant increases in the mean frequency (t1,28 = 3.925, p < 0.001; Figure 6D) and amplitude (t1,28 = 3.568, p = 0.001; Figure 6E) of mIPSCs in 3 × Tg-AD mice. This evidence concerns the gene GSK3B and Alzheimer disease.