Additionally, it has been shown that microglia and astrocytes were activated in the prefrontal cortex and hippocampus during the early stage of the disease and significantly increased with the disease progresses in different transgenic mouse models of AD, including Tg2576 [6], APP/PS1 [7], 5 × FAD [8], and 3 × Tg-AD [9,10] mice. The gene discussed is APP; the disease is Alzheimer disease.