Treadmill exercise led to decreases in the levels of soluble Aβ trimers, kinase activity of GSK3β, the concentrations of pro-inflammatory cytokines (IL-1β, IL-6, and TNFα), and the phosphorylation of CRMP2 at Thr514 in the prefrontal cortex of 3 × Tg-AD mice. The gene discussed is IL1B; the disease is Alzheimer disease.