LRRK2 and Parkinson disease: Comparisons of the results of these studies reveal high within- and between-study variability even with very similar protocols, but particularly high-dose oral rotenone looked promising and has been used as a PD model in multiple studies exploring drug, diet, stress, or LRRK2 effects in mice [23,25,26,27,28,29,30,36,39,43,44,45].