HCRT and breast carcinoma: In addition, the orexin system is found to be associated with breast cancer in animal models: activation of LHA orexin neurons in a mouse model of breast cancer leads to sleeping disruption and metabolic abnormality complicated by tumors, and this effect occurs via the sympathetic system as it can be blocked by 6-hydroxydopamine, a selective catecholaminergic neurotoxin [39].