Other tumor suppressor genes, such as cyclin-dependent kinase inhibitor 2A (CDKN2A), retinoblastoma (Rb), Von Hippel–Lindau (VHL), and breast cancer 1 (BRCA1) have also been identified in the cancer cells as being inactivated via an ROS-dependent epigenetic modulation [123,124]. The gene discussed is BRCA1; the disease is cancer.