Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) is a member of the IL-10 family of cytokines and has been confirmed to have anti-angiogenic, radiosensitizing, immunostimulatory and anti-tumor bystander effects [209,210,211], as well as inducing growth inhibition and apoptosis in various human cancers, including PCa, without any harmful effects on normal cells [212,213,214,215]. The gene discussed is IL24; the disease is cancer.