A study by Pandey et al. showed that both doses of esculetin (50 and 100 mg/kg) improve the phospho-Forkhead box protein O1 (FOXO1) expression by acting on the Akt/P13K/FOXO1 pathway, which further results in the amelioration of TGF-β-mediated hepatic fibrosis in HFD fed rats. This evidence concerns the gene TGFB1 and Hepatic fibrosis.