The carriage of several specific genotype combinations of the MMP9 gene had the most pronounced BC risk effect (beta = 1.54–1.61 and p = 0.0001–0.0004): GA(rs17577) × CC(rs2250889) × CC(rs3918242), GG(rs17577) × CC(rs2250889) × CT(rs3918242), GA(rs17577) × CC(rs3918242), GG(rs17577) × CT(rs3918242) (Supplementary Table S2). The gene discussed is MMP9; the disease is breast cancer.