Further analysis of the visceral fat showed increased NE turnover as well as enhanced β1, β2, and β3 adrenergic receptor (β1AR, β2AR, and β3AR) mRNA levels, indicating enhanced NE signaling in the visceral fat (Figure 4C,D), thus protecting dbh-CB1-KO mice against HFD-induced obesity. The gene discussed is ADRB3; the disease is obesity due to melanocortin 4 receptor deficiency.