Mechanistically, exosomal miR-146a-5p has been shown to confer prostate cancer cells metastatic abilities through EGFR/ERK pathway [65], downregulate BRCA1 in triple negative sporadic BCs [68] and play a central role within the STAT/IFN signaling axis to create an immunosuppressive microenvironment [69,70]. This evidence concerns the gene BRCA1 and Familial prostate cancer.