In particular, the following miRNAs have been associated with this neuroprotective function: miR-193a-3p [170] and miR-133b [171] in human serum, miR-335-5p [172] and miR-361-3p [173] in the human brain, miR-200a-3p [174] in plasma from AD patients, miR-107 [175] in human neuroblast cell lines, and miR-340 [176] in the hippocampus from senescence-accelerated (SAMP8) mice that show increased oxidative damage associated with APP overproduction. Here, APP is linked to Alzheimer disease.