Moreover, several ALS-related genes (DENND11, COL15A1, TARDBP, RANGAP1, and IGHMBP2) and DNA repair genes (OGG1, APEX1, PNKP, and APTX) are differentially methylated in ALS patients [44,45,46]. Here, DENND11 is linked to amyotrophic lateral sclerosis.