LRRK2 and Parkinson disease: A whole-genome bisulfite sequencing study using induced pluripotent stem cell (iPSC)-derived dopaminergic neurons from sporadic PD and monogenic LRRK2 (Leucine-rich repeat kinase 2)-associated PD patients revealed global DNA hypermethylation associated with disease [37], conversely to the hypomethylation observed in blood and saliva.