However, HDAC4 expression is decreased in the skeletal muscle of ALS patients [79], and the skeletal muscle-specific ablation of HDAC4 is sufficient to induce an earlier onset of the disease, a decrease in neuromuscular junctions’ size, and muscle denervation and atrophy in SOD1-ALS mice [80]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.