Photo-documentation of CAM tumors developing from inoculated RB cells (Figure 6a,b) and quantification of tumor weight (Figure 6c) and size (Figure 6d) revealed that ADAM17 single and ADAM10/17 double depleted RB cells develop significantly smaller tumors (Figure 6a,b) than control cells, with lower weight and size (Figure 6c,d). This evidence concerns the gene ADAM17 and neoplasm.