Our group recently demonstrated that ADAM10 and ADAM17 are involved in ectodomain shedding of the cell adhesion molecule L1CAM in retinoblastoma (RB) cell lines, potentially influencing L1CAM-mediated effects on RB tumor formation and migration capacity in vivo, as well as apoptosis and cell proliferation in vitro [14]. This evidence concerns the gene ADAM10 and retinoblastoma.