Next, the addition of the 15 early RA to the 69 non-RA (Figure 2B–E) retrieved three negative associations with oral Porphyromonas sp.: DAS28-ESR (p = 0.01, LDA = −2.3), MTX use (p = 0.01, LDA = −2.4), and ACPA positivity (p = 0.015, LDA = −2.4). Here, PRTN3 is linked to rheumatoid arthritis.