In the venetoclax and A1331825 combination treated AML gene mutation status of TET2, FLT3, and TP53 as well as CD34, levels were inconsequential, IDH2 mutation and elevated blast cell percentage were associated with response, while the presence of PTPN11 or ASXL1 mutation indicated lack of response (Figure 7). The gene discussed is PTPN11; the disease is acute myeloid leukemia.