Altered-immunosuppressed tumor shows an intermediate degree of T cell and CTL infiltration and immunoscore, T cell checkpoints (PD-1, CTLA-4, TIM3, and LAG3), immune suppressive cells (MDSC and Treg), and inhibitory cytokines (TGF-, IL-10 and VEGF). The gene discussed is HAVCR2; the disease is neoplasm.