It has been found in in vitro co-culture study that conditioned media by human ATC cells (8505c and KTC-2) are involved in reprogramming of thyroid fibroblast phenotype to CAF phenotype [74], and conditioned media by thyroid cancer cells that are induced by BRAF mutation promote CAF proliferation and migration in thyroid cancer mouse model [73]. The gene discussed is BRAF; the disease is thyroid cancer.