TNF and neoplasm: TAN, like TAM, can also differentiate into anti-tumor type (N1) and pro-tumor type (N2) [35,36,37]; N1 TAN have high levels of TNFα, CCL3, and ICAM-1 and low levels of arginase, whereas N2 TAN show high levels of CCL2, CCL3, CCL4, CCL8, CCL12, CCL17, CXCL1, CXCL2, IL-8/CXCL8, and CXCL16 [36,37].