CXCL12 and neoplasm: Growth factors such as HGF, VEGF, EGF, CTGF, IGF, and NGF, cytokines such as IL-6, IL-11, and IL-17, and chemokines such as CCL7, CCL5, CXCL12, and CXCL7 are produced by CAF in the process of interaction between tumor cells and CAF [18].