One meta-analysis [33] including more than 10,000 AD patients and healthy controls revealed that IL-1β; IL-2; IL-6; IL-18; IFN-γ; high-sensitivity CRP; C-X-C motif chemokine-10, a TNF-α converting enzyme; and soluble TNF receptors 1 and 2 are elevated in the peripheral system. This evidence concerns the gene IL1B and Alzheimer disease.