We discovered that some cell cycle and cytokinesis genes, such as RRM2 (ribonucleotide reductase regulatory subunit M2), HDAC6 (histone deacetylase), ring finger and WD repeat domain 3 (RFWD3), E2F associated phosphoprotein (EAPP), G2 and S-phase expressed 1 (GTSE1), U2AF homology motif kinase 1 (UHMK1) and stathmin 1 (STMN1) were downregulated in non-obstructive azoospermia. The gene discussed is EAPP; the disease is Azoospermia.