Our findings show that WD repeat domain 90 (WDR90), telomerase associated protein 1 (TEP1), non-SMC condensin I complex subunit G (NCAPG), the establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), kinesin family member 4A (KIF4A), PWWP domain containing 2A (PWWP2A), and INO80 complex subunit C were downregulated in Sertoli of non-obstructive azoospermia. The gene discussed is PWWP2A; the disease is Azoospermia.