Martínez-Esparza et al. reported that blood monocytes exhibited higher LAIR-1 expression levels in cirrhotic patients and emphasized that liver cirrhosis is characterized by a progressive replacement of the functional hepatic architecture by nonfunctional fibrotic tissue, which is rich in the immunoinhibitory LAIR-1 ligand, collagen deposition [11]. Here, LAIR1 is linked to cirrhosis of liver.