Since the lipid biosynthesis pathways are reprogramed and upregulated in these lung cancer cells, the expressions of several key transcriptional regulators, including CCAAT/enhancer-binding proteins (C/EBPs), hypoxia-inducing factor (HIF-1α), sterol regulatory element-binding protein/factor-1 (SREBP-1), peroxisome proliferator-activated receptor (PPARs) [22], and regulating lipogenesis, were investigated. The gene discussed is SREBF1; the disease is lung cancer.