Given our previous studies have shown that ISO inhibits invasive BC formation in vivo and human BC invasion in vitro by targeting the STAT1/FOXO1 Axis, and MMP2 is negatively transcriptional regulated by FOXO1 and acts as a FOXO1 downstream effector for the ISO inhibition of BC invasion [16], we evaluated whether SOX2-initiated FOXO1 downregulation led to MMP2 induction. Here, MMP2 is linked to breast cancer.