To understand the mechanism by which SOX2 regulates BC cell invasion, we compared essential proteins related to the regulation of BC invasion including RhoGDIα, RhoGDIβ, Src FOXO1, and MMP2 between T24 and T24T, T24(Vector) and T24(SOX2), and T24T(Vector) and T24T(KOSOX2 C1/C2) cells. This evidence concerns the gene SOX2 and breast cancer.