To understand the mechanism by which SOX2 regulates BC cell invasion, we compared essential proteins related to the regulation of BC invasion including RhoGDIα, RhoGDIβ, Src FOXO1, and MMP2 between T24 and T24T, T24(Vector) and T24(SOX2), and T24T(Vector) and T24T(KOSOX2 C1/C2) cells. The gene discussed is MMP2; the disease is breast cancer.